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21/05/2025

The rise and rise of proteostasis

This feature was written by Becky Allen for the 2023-2024 Â鶹ÊÓƵ Review.

Proteostasis, the myriad mechanisms that ensure our proteins work correctly, is key to healthy ageing. We speak to Dr Della David and Dr Rahul Samant about their cutting-edge research, why proteostasis is such a growing area of strength at the Â鶹ÊÓƵ, and how the new UK Proteostasis Network will help accelerate research in the field.

20/05/2025

Adapting to change and challenge

This feature was written by Becky Allen for the 2023-2024 Â鶹ÊÓƵ Review.

Understanding how things work underpins the Â鶹ÊÓƵ’s past, present and future. Dr Simon Cook, Â鶹ÊÓƵ Director and head of the Signalling programme, explains why he’s an evangelist for discovery research, how this quest for understanding is reflected in the Â鶹ÊÓƵ’s science, its people and the ecosystem of the Babraham Research Campus, and looks ahead to the next four years’ work.

18/12/2023

From tiny worms to big discoveries

This feature was written by Becky Allen for the 2021-2022 Review.

Dr Della David reflects on her first 12 months at the Â鶹ÊÓƵ, reveals the roots of her own scientific curiosity, and explains how a tiny, transparent, short-lived worm is enabling her to discover new ways of promoting healthy ageing.

18/12/2023

Time flies

This feature was written by Becky Allen for the 2021-2022 Review.

Joining a new organisation and building your research team during a pandemic isn’t ideal but new group leader Dr Ian McGough is pleased he’s found his niche, and gorgeous trail running routes, alongside a very warm welcome.

29/11/2021

A remarkable partnership

This feature was written by Becky Allen for the Annual Research Report 2019-2020.

Great science depends on teamwork, yet genuine partnerships are rare, especially those which sustain success over decades. Dr Len Stephens and Dr Phill Hawkins, both group leaders in the Â鶹ÊÓƵ’s Signalling programme, have worked together for more than 30 years. Here, they reflect on their research, their relationship – and their distinctly different approaches to fishing.

29/11/2021

Back to basics

This feature was written by Becky Allen for the Annual Research Report 2019-2020.

Setting up a new group is exciting and daunting. Two group leaders who joined the Signalling programme in 2019 – Dr Hayley Sharpe and Dr Rahul Samant – talk about their research and the supportive, collaborative and open environment that they say marks out the Â鶹ÊÓƵ.

05/08/2019

Welcome to the lipidome

This feature was written by Becky Allen for the Annual Research Report 2018

Once neglected as too dull to study and too sticky to work with, lipids are at last stepping out of the shadows. Â鶹ÊÓƵ Director Michael Wakelam and lipidomics facility manager Andrea Lopez-Clavijo explain the challenges of working with these cellular Cinderellas and share their excitement of research in a field that’s finally giving up its secrets.

01/07/2018

Making the Most of Signalling Research

This feature was written by Becky Allen for the Annual Research Report 2017

Bringing together the Â鶹ÊÓƵ’s researchers with scientists in the 60 companies on the Babraham Research Campus is helping turn innovative ideas into new benefits for human health – fast. Over the past two years, members of the Signalling research programme have transformed a conversation over coffee into a collaboration that could deliver new ways of treating some of the most intractable human cancers.

01/05/2017

The quiet pathway

This feature was written by Becky Allen for the Annual Research Report 2016

For many years regarded as merely a cell biological process, autophagy is now implicated in many diseases. Thanks to progress made in the Signalling research programme this year autophagy – the mechanism cells use to recycle unwanted or damaged components to create molecules they need – is now understood in greater detail than ever before. We find out how research at the Â鶹ÊÓƵ could harness autophagy to help us age more healthily.